Thyroxine

Indications

Central hypothyroidism is diagnosed by low free T4 combined with low, normal or mildly elevated TSH.

Dose

The typical replacement dose is 1.6 mcg/kg/day (e.g., 70 kg man would require ~ 100-125 mcg/day).

Monitoring the Adequacy of Replacement

In patients with central hypothyroidism, monitor free T4, not TSH.

Counseling

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