Cabergoline

Indications

  1. Prolactin producing pituitary adenomas (first-line).
  2. GH- and TSH- producing pituitary adenomas (as an adjunct).

Dosage

Typical cabergoline dose is 0.5 to 2.0 mg per week, in 2-4 divided doses. E.g., 0.5 mg twice weekly.

Some aggressive/resistant prolactinomas (~ 10-15%) require higher doses.

Tapering

Cabergoline may be tapered and stopped, with careful monitoring, in patients with the following criteria:

  1. Received 2 years of treatment with a dopamine-agonist
  2. Normal serum prolactin.
  3. No visible tumour on MRI.

Pregnancy

References