Desmopressin Stimulation

Indications

Differentiate between Cushing’s disease and pseudocushing’s.

Procedure

Measure plasma ACTH at baseline, 10 min, 20 min, and 30 min after administration of ddAVP 10 μg intravenously.

Interpretation

ACTH increase over baseline by ≥ 6 pmol/L after ddAVP indicates Cushing’s disease (Sn 81·5%, Sp 90%). [Giraldi 2007]

Caveats

The utility of the test has not been validated in a large population of patients with all causes of Cushing’s syndrome. [Nieman 2008]

References